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Omega-6/Omega-3 ratio was found higher in infertile men (less fertile), it is according to findings from a study involving approximately 150 men in Iran, as published in the journal Clinical Nutrition in 2009. As we know also that the composition of fatty acids (Fatty acid) on the role in the fertility of spermatozoa (fertility) men.

As background, clinical studies conducted by Dr. Safarinejad from Shahid Beheshti University in Tehran, Iran, by evaluating the composition of long chain fatty acids that are not saturated (polyunsaturated fatty acids) in blood plasma and spermatozoa in infertile men (infertile) with the idiopathic oligoasthenoteratozoospermia (OAT).



Dr. Safarinejad and colleagues measured the levels of long chain fatty acids are not saturated (polyunsaturated fatty acids) of blood plasma and spermatozoa from 82 infertile men with idiopathic OAT and 78 fertile men who determined the concentration of semen and proven fertile follow this study. Semen parameters input based on WHO criteria; 3 levels of Omega-3 fatty acids - ALA (Alpha linolenic acid), EPA (Eicosapentaenoic acid) and docosahexaenoic acid (DHA) and Omega 2-6 - (linoeic acid) and arakhidonat acid (arachidonic acid ) is measured in blood plasma and spermatozoa; and the levels of antioxidant enzymes catalase and Superoxide dismutase (SOD) in plasma seminal fluid are also included in this clinical study.




From the results of this study found that in proven fertile men who had levels of Omega-3 fatty acids are higher than male subjects who are infertile (infertile). Serum ratio of omega-6 / omega-3 fatty acids significantly higher in infertile men (14.8 ± 4.3) compared to a fertile male controls (6.3 ± 2.2) (p = 0.001). In addition, levels of arachidonic acid and higher omega-3 index (EPA + DHA) was lower in infertile subjects compared to fertile controls (all P values <0.05). Infertile men have an average content ratio of AA: DHA and the ratio of AA: EPA (respectively 6.4 ± 2.9 and 12.0 ± 4.9) compared to fertile men (respectively 3.3 ± 1.8 and 6.7 ± 2.6) (both P = 0.001). Strong negative correlation was found between the ratio of AA: DHA and the ratio of AA: EPA and total sperm count (respectively r = -0.62, P = 0.001 and r = -0.64, P = 0.001), sperm motility (r =- 0.63, p = 0.001 and r = -0.61, p = 0.001) and sperm morphology (respectively r =- 0.61, p = 0.001 and r = -0.59, P = 0.002) .

In conclusion Dr clinical studies. Safarinejad et al, shows a man infertile (not fertile) have concentrations of omega-3 lower than men on spermatozoa fertile (fertile), and he thinks and his colleagues proposed the study group benefits / potential of supplementing omega-3 to treatment of infertile men with idiopathic OAT. However according to Dr. Safarinejad, was also required confirmation by a larger study, prospective study to follow up this future, because this study can not be generalized to other populations.