Doctor world

Dr. Soo-Jeong Cho and colleagues from Seoul National University College of Medicine found that simvastatin can prevent the development of cancer in mice kolon with menginduksi pressing apoptosis and angiogenesis. Results of this research are published in the journal International Journal of Cancer August 2008 edition.

Simvastatin, the statin drugs antihiperlipidemia, is estimated to reduce the risk of cancer occurrence kolorektal. Dr. Soo-Jeong Cho and colleagues found that simvastatin can prevent bookmarks (signaling) of the NF-kappaB in human intestinal cells epitel and kolitis improve conditions in the rat.

Dr. Cho and colleagues conducted a study that aims to examine the influence of simvastatin on the path of apoptosis-related marker (signaling) NF-kappaB in cancer cells kolon and antikankernya effect on the animal model of 2 different experiment.

Dr. Cho simvastatin therapy or to provide control (vehicle) on the 2 cell culture (CoLo 205 and HCT). Apoptosis determined by cell cycle analysis, coloring Annexin V-FITC, caspase-3 activity assay and confocal microscopy. Expression of antiapoptosis factors assessed with RT-PCR and Western blotting.

In the CAC model (colitis-associated colon cancer), tumor kolon diinduksi in C57/BL6 mice with azoxymethane and dextran sodium sulfate, the evaluation conducted to determine the influence of simvastatin on tumor growth. In the model to 2, the xenograft (cell cangkok), conducted the evaluation of the influence of simvastatin to tumor growth diinokulasi.

Research results showed that simvastatin in both cell culture experiments can cause death of cells that depend on the dose and time (time-and dose-dependent cell death). Tint with Annexin V increased after therapy with the means with simvastatin. Simvastatin increase caspase-3 activity and down regulation Bcl-2 expression, Bcl-XL, cIAP1 and cFLIP. In the CAC model, simvastatin with the means to reduce tumor growth. While in the xenograft model, the size of the tumor diterapi with simvastatin smaller regions have greater nekrosis, VEGF expression and a lower value have a higher apoptosis.




Dr. Cho and colleagues conclude that simvastatin can prevent the development of cancer kolon with menginduksi pressing apoptosis and angiogenesis. Simvastatin can be estimated kemopreventif a potential drug for cases of cancer caused kolon colitis and cancer kolon de Novo.

Conclusion:



* In animal experiments, simvastatin can prevent tumor growth kolon, kolon both tumor-related kolitis, and the tumor kolon de Novo.
* The influence of simvastatin on human tumor kolon not yet known. Please do more research about this.
* The question is, why apoptosis effect of simvastatin on cell tumor occurred, and whether there apoptosisnya effects on healthy cells?